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This maternal immunization hypothesis MIH begins when cells from a male fetus enter the mother's circulation during pregnancy or while giving birth. How do twins who differ in their sexual experiences differ in their later development? Some studies have seen pre-natal hormone exposures as the primary factor involved in determining sexual orientation. A meta-analysis of 48 studies showed childhood gender nonconformity to be the strongest predictor of a homosexual orientation for both men and women. Female relatives of the homosexual men tended to have more offspring than those of the heterosexual men. However, the INAH3 group appeared to be twice as big in the heterosexual male group as in the gay male group; the difference was highly significant, and remained significant when only the six AIDS patients were included in the heterosexual group. Although not referring to the study of sexual behavior specifically, Freese aptly summarized a common attitude within the social sciences toward genetics:

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Genetic links sexual behavior. Twin studies[ edit ] A number of twin studies have attempted to compare the relative importance of genetics and environment in the determination of sexual orientation.

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